IL27 Receptor alpha antibody (C-Term)

Catalog No. ABIN500877

This anti-IL27 Receptor alpha antibody is a Rabbit Polyclonal antibody detecting IL27 Receptor alpha in WB, IHC (p) and EIA. Suitable for Human and Mouse.

Quick Overview for IL27 Receptor alpha antibody (C-Term) (ABIN500877)

Target: IL27 Receptor alpha (IL27RA) (Interleukin 27 Receptor, alpha (IL27RA))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL27 Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-IL27 Receptor alpha Antibody

Binding Specificity: C-Term

Specificity: This antibody detects TCCR / IL27RA at C-term.

Cross-Reactivity (Details): Species reactivity (expected):MouseSpecies reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogen: TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of human TCCR precursor. Remarks: The sequence is identical to that of mouse TCCR.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for IL27 Receptor alpha

Target: IL27 Receptor alpha (IL27RA) (Interleukin 27 Receptor, alpha (IL27RA))

Alternative Name: TCCR / IL27RA

Background: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned (1,2). It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1 (1,2). TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a . TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.Synonyms: CRL1, IL-27R-alpha, Interleukin-27 receptor subunit alpha, T-cell cytokine receptor type 1, UNQ296/PRO336, WSX-1, WSX1

Gene ID: 9466

NCBI Accession: NP_004834

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response