PRNP antibody (AA 23-120) (AbBy Fluor® 750)
Quick Overview for PRNP antibody (AA 23-120) (AbBy Fluor® 750) (ABIN5009163)
Target
See all PRNP AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 23-120
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Predicted Reactivity
- Human,Mouse,Rat,Cow,Horse
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Purification
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human PRNP
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Isotype
- IgG
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Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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Expiry Date
- 12 months
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- PRNP (Prion Protein (PRNP))
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Alternative Name
- Prion protein PrP/CD230
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Background
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Synonyms: AltPrP, ASCR, atal familial insomnia, CD230, CD230 antigen, CJD, Creutzfeld Jakob disease, Gerstmann-Strausler-Scheinker syndrome, GSS, KURU, Major prion protein, PRIO_HUMAN.
Background: The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis (By similarity). Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).
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Gene ID
- 5621
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UniProt
- P04156
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Pathways
- Transition Metal Ion Homeostasis, Activated T Cell Proliferation
Target
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