TMEM38A antibody (C-Term)

Catalog No. ABIN500984

The Rabbit Polyclonal anti-TMEM38A antibody has been validated for WB and EIA. It is suitable to detect TMEM38A in samples from Human, Rat and Mouse.

Quick Overview for TMEM38A antibody (C-Term) (ABIN500984)

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM38A antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-TMEM38A Antibody

Binding Specificity: C-Term

Specificity: This antibody detects TMEM38A.

Purification: Peptide affinity chromatography

Immunogen: TMEM38A antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human TMEM38A.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TMEM38A

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Alternative Name: TMEM38A

Background: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.Synonyms: TRIC-A, TRICA, Transmembrane protein 38A, Trimeric intracellular cation channel type A

Gene ID: 79041