TMEM38A antibody (C-Term)

Catalog No. ABIN6991239

Product Details anti-TMEM38A Antibody

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM38A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: TMEM38A Antibody is affinity chromatography purified via peptide column.

Immunogen: TMEM38A antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A. The immunogen is located within the last 50 amino acids of TMEM38A.

Isotype: IgG

Application Details

Application Notes: TMEM38A antibody can be used for detection of TMEM38A by Western blot at 1 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TMEM38A Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TMEM38A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TMEM38A

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Alternative Name: TMEM38A (TMEM38A Products)

Synonyms: zgc:77831 antibody, MGC75707 antibody, TMEM38A antibody, TRIC-A antibody, TRICA antibody, 1110001E17Rik antibody, AI413399 antibody, mg33a antibody, RGD1307901 antibody, Srp-27 antibody, transmembrane protein 38A antibody, transmembrane protein 38a antibody, transmembrane protein 38A L homeolog antibody, tmem38a antibody, CpipJ_CPIJ011791 antibody, CpipJ_CPIJ013655 antibody, TMEM38A antibody, Tmem38a antibody, tmem38a.L antibody

Background: TMEM38A Antibody: TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure, the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Gene ID: 79041

UniProt: Q9H6F2