CRLF2 antibody (Center)

Catalog No. ABIN501085

This Rabbit Polyclonal antibody specifically detects CRLF2 in WB and EIA. It exhibits reactivity toward Mouse.

Quick Overview for CRLF2 antibody (Center) (ABIN501085)

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRLF2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CRLF2 Antibody

Binding Specificity: Center

Specificity: This antibody detects CRLF2.

Cross-Reactivity (Details): Species reactivity (tested):Mouse

Purification: Peptide affinity chromatography

Immunogen: TSLP receptor antibody was raised against a 21 amino acid peptide from near the center of mouse TSLP receptor.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for CRLF2

Target: CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))

Alternative Name: CRLF2

Background: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells, co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75 kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.Synonyms: Cytokine receptor-like 2, Cytokine receptor-like factor 2, IL-XR, ILXR, TSLPR, Thymic stromal lymphopoietin protein receptor

Gene ID: 57914

NCBI Accession: NP_057924