TTBK1 antibody (C-Term)

Catalog No. ABIN501089

The Rabbit Polyclonal anti-TTBK1 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect TTBK1 in samples from Human and Mouse.

Quick Overview for TTBK1 antibody (C-Term) (ABIN501089)

Target: TTBK1 (Ttbk1) (tau Tubulin Kinase 1 (Ttbk1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTBK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-TTBK1 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects TTBK1. It is predicted to not cross-react with TTBK2.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography

Immunogen: TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for TTBK1

Target: TTBK1 (Ttbk1) (tau Tubulin Kinase 1 (Ttbk1))

Alternative Name: TTBK1

Background: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist.Synonyms: BDTK, Brain-derived tau kinase, KIAA1855, Tau-tubulin kinase 1

Gene ID: 84630

UniProt: Q5TCY1