SYK antibody (pTyr323) (AbBy Fluor® 680)

Catalog No. ABIN5011205

This anti-SYK antibody is a Rabbit Polyclonal antibody detecting SYK in WB. Suitable for Human, Mouse and Rat.

Quick Overview for SYK antibody (pTyr323) (AbBy Fluor® 680) (ABIN5011205)

Target: SYK (Spleen tyrosine Kinase (SYK))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYK antibody is conjugated to AbBy Fluor® 680

Application: Western Blotting (WB)

Product Details anti-SYK Antibody (AbBy Fluor® 680)

Binding Specificity: pTyr323

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Syk around the phosphorylation site of Tyr323

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SYK

Target: SYK (Spleen tyrosine Kinase (SYK))

Alternative Name: Syk

Background:

Synonyms: syk Tyr323, Tyrosine-protein kinase SYK Spleen tyrosine kinase [Contains: 72 kDa tyrosine-protein kinase SYK, 40 kDa tyrosine-protein kinase SYK, KSYK_HUMAN.

Background: Syk (72 kDa) is a non receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions. Alternate Names: p72syk, Spleen tyrosine kinase, Tyrosine protein kinase SYK.

Gene ID: 6850

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling