beta Arrestin 1 antibody (AA 150-318)

Catalog No. ABIN5027057

The Rabbit Polyclonal anti-beta Arrestin 1 antibody (ABIN5027057) specifically detects beta Arrestin 1 in WB. The antibody is reactive with Human samples.

Quick Overview for beta Arrestin 1 antibody (AA 150-318) (ABIN5027057)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Arrestin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-beta Arrestin 1 Antibody

Binding Specificity: AA 150-318

Purification: Protein A Chromatography

Immunogen: A partial length recombinant Beta-arrestin 1 protein (amino acids 150-318) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 2-4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Alternative Name: Beta-arrestin 1

Background: Beta-arrestin 1, a member of arrestin family, is a cofactor of beta-adrenergic receptor kinase (BARK) in beta-adrenergic receptor desensitization and resensitization process. Beta-arrestin 1 acts as endocytic adapter for internalization of many G-protein coupled receptors. Beta-arrestin 1 is also associated with many other cellular processes like ubiquitination and down-regulation of the insulin-like growth factor-1 receptor, synaptic transmission in photoreceptor cells, working as a scaffold protein in G-protein coupled receptor signaling pathways. Two isoforms of beta-arrestin 1 have been identified, isoform 1 (47 kDa) and isoform 2 (46 kDa). Beta-arrestin 1 is highly expressed in liver, kidney, lungs and testes.

Molecular Weight: 47 kDa

Gene ID: 408

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction