CD33 antibody (AA 28-320)

Catalog No. ABIN5027091

This Mouse Monoclonal antibody specifically detects CD33 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for CD33 antibody (AA 28-320) (ABIN5027091)

Target: CD33

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD33 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: ABM29D3

Product Details anti-CD33 Antibody

Binding Specificity: AA 28-320

Purification: Protein G Chromatography

Immunogen: A partial length recombinant CD33 protein (amino acids 28-320) was used as the immunogen for this antibody.

Isotype: IgG2a kappa

Application Details

Application Notes: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for CD33

Target: CD33

Alternative Name: CD33

Background: CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs). CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia). The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.

Molecular Weight: 39 kDa

Gene ID: 945

UniProt: P20138