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CD73 antibody (AA 145-346)

The Mouse Monoclonal anti-CD73 antibody has been validated for WB and IHC. It is suitable to detect CD73 in samples from Human.
Catalog No. ABIN5027098

Quick Overview for CD73 antibody (AA 145-346) (ABIN5027098)

Target

See all CD73 (NT5E) Antibodies
CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

Reactivity

  • 177
  • 70
  • 36
  • 19
  • 18
  • 16
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 108
  • 89
  • 14
  • 2
  • 2
  • 1
Mouse

Clonality

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  • 95
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Monoclonal

Conjugate

  • 96
  • 19
  • 16
  • 7
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  • 5
  • 4
  • 4
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  • 4
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  • 4
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  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This CD73 antibody is un-conjugated

Application

  • 150
  • 116
  • 112
  • 55
  • 45
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  • 1
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Western Blotting (WB), Immunohistochemistry (IHC)

Clone

ABM40E2
  • Binding Specificity

    • 16
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    • 9
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    • 6
    • 5
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    AA 145-346

    Purification

    Protein G Chromatography

    Immunogen

    A partial length recombinant CD73 protein (amino acids 145-346) was used as the immunogen for this antibody.

    Isotype

    IgG2a kappa
  • Application Notes

    WB: 2-4 μg/mL, IHC: 5 μg/mL

    Restrictions

    For Research Use only
  • Concentration

    0.5 mg/mL

    Buffer

    PBS containing 0.05 % BSA, PH 7.4

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C/-20 °C

    Storage Comment

    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • Target

    CD73 (NT5E) (5'-Nucleotidase, Ecto (CD73) (NT5E))

    Alternative Name

    CD73

    Background

    CD73, also known as ecto-5'-nucleotidase, is a glycosyl-phosphatidylinositol linked plasma membrane glycoprotein that is expressed on multiple cell types and in different tissues. It is a key enzyme in the regulation of purinergic signaling and inflammatory reactions. It hydrolyzes extracellular AMP into adenosine, which dampens immune cell activation, and reduces leukocyte trafficking CD73 potently suppresses antitumor T cell responses through its ability to generate adenosine. It has also emerged as an important regulator of tissue homeostasis and pathophysiologic responses related to immunity, inflammation, pain, ischemia, tissue fibrosis and cancer.

    Molecular Weight

    63 kDa

    Gene ID

    4907

    UniProt

    P21589

    Pathways

    Synaptic Membrane, Ribonucleoside Biosynthetic Process
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