OLR1 antibody (AA 1-200)

Catalog No. ABIN5027116

The Rabbit Polyclonal anti-OLR1 antibody has been validated for WB. It is suitable to detect OLR1 in samples from Human.

Quick Overview for OLR1 antibody (AA 1-200) (ABIN5027116)

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OLR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OLR1 Antibody

Binding Specificity: AA 1-200

Purification: Protein A Chromatography

Immunogen: A partial length recombinant CLEC8A protein (amino acids 1-200) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 5-6 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for OLR1

Target: OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))

Alternative Name: CLEC8A/LOX-1/OLR1

Background: CLEC8A or OLR1 is a member of C-type lectin super family. It is the receptor that mediates the recognition and degradation of low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in inflammatory responses, pro-oxidative conditions and apoptosis. OLR1 ligation with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, Monocyte adhesion and apoptosis. OLR1 is highly expressed in vascular rich organs, like placenta, liver, lungs and brain. CLEC8A has been reported to be associated with diseases, like atherosclerosis, myocardial infarction and Alzheimer's disease. Alternative splicing produces three isoforms of CLEC8A or OLR1 whose exact function is yet to be ascertained.

Molecular Weight: 21 kDa (Isoform)

Gene ID: 4973

UniProt: P78380