MUM1 antibody (AA 52-278)

Catalog No. ABIN5027376

This Rabbit Polyclonal antibody specifically detects MUM1 in WB. It exhibits reactivity toward Human.

Quick Overview for MUM1 antibody (AA 52-278) (ABIN5027376)

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MUM1 Antibody

Binding Specificity: AA 52-278

Purification: Protein A Chromatography

Immunogen: A partial length recombinant MUM1 protein (amino acids 52-278) was used as the immunogen for this antibody.

Isotype: IgG

Application Details

Application Notes: WB: 1-2 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for MUM1

Target: MUM1 (Melanoma Associated Antigen (Mutated) 1 (MUM1))

Alternative Name: MUM1

Background: MUM1 is a member of the interferon regulatory factor family of transcription factors. This protein is required at several stages of B-cell development, including in the differentiation of mature B cell into antibody-secreting plasma cells, and is also critical for Th2 and Th17 T-cell differentiation and T-cell cytotoxic function. MUM1 is normally expressed in plasma cells, melanocytes, some B cells, and activated T cells. MUM1 acts as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. MUM1 acts as a helpful marker in the differential diagnosis of AITL(Angioimmunoblastic T cell Lymphoma with HRS-like cells and cHL.

Molecular Weight: 78 kDa

Gene ID: 84939

UniProt: Q2TAK8

Pathways: Chromatin Binding