PTH antibody (AA 1-236)

Catalog No. ABIN5027426

This anti-PTH antibody is a Mouse Monoclonal antibody detecting PTH in IHC and WB. Suitable for Human.

Quick Overview for PTH antibody (AA 1-236) (ABIN5027426)

Target: PTH (Parathyroid Hormone (PTH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTH antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Clone: ABM4D44

Product Details anti-PTH Antibody

Binding Specificity: AA 1-236

Purification: Protein G Chromatography

Immunogen: A partial length recombinant Parathyroid Hormone protein (amino acids 1-236) was used as the immunogen for this antibody

Isotype: IgG2b kappa

Application Details

Application Notes: WB: 2-4 μg/mL, IHC: 5 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for PTH

Target: PTH (Parathyroid Hormone (PTH))

Alternative Name: Parathyroid Hormone

Target Type: Hormone

Background: Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral homeostasis by regulating calcium and phosphate absorption/reabsorption. It modulates phosphate homeostasis by downregulating Dentin matrix acidic phosphoprotein 1(DMP1) expression via the cAMP/PKA pathway targeting genes/proteins mutually governed by PTH. PTH secretion is characterized by an ultradian rhythm with tonic and pulsatile components. The majority of PTH is secreted in tonic fashion. Changes in the ultradian PTH secretion are correlated with skeletal fragility in primary and secondary osteoporosis. Plasma concentrations of Zn ions levels were significantly correlated with PTH levels. PTH in serum is typical for patients with chronic kidney disease (CKD). The onset of CKD is associated with pathway changes of protein synthesis and metabolism, amino acid metabolism, energy metabolism, and steroid hormone metabolism. Parathyroid hormones are bone-forming agents that have different modes of action on the bone. Lack of PTH in the central nervous system causes Hypoparathyroidism (HPT).

Molecular Weight: 59 kDa

Gene ID: 5745

UniProt: Q03431

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process