Bax Inhibitor 1 antibody (AA 1-200)

Catalog No. ABIN5027485

The Mouse Monoclonal anti-Bax Inhibitor 1 antibody has been validated for WB. It is suitable to detect Bax Inhibitor 1 in samples from Human.

Quick Overview for Bax Inhibitor 1 antibody (AA 1-200) (ABIN5027485)

Target: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Bax Inhibitor 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABM20E4

Product Details anti-Bax Inhibitor 1 Antibody

Binding Specificity: AA 1-200

Purification: Protein G Chromatography

Immunogen: A partial length recombinant protein of human Bi-1 (amino acids 1-200) was used as an immunogen for this antibody.

Isotype: IgG2b kappa

Application Details

Application Notes: WB: 4-6 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Target Details for Bax Inhibitor 1

Target: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Alternative Name: Bi-1

Background: Bi-1 is an anti-apoptotic protein that inhibits Bax activation and its translocation to the mitochondria. Functionally, BI-1 affects the leakage of Ca2+ ions from the ER. In addition to its anti-apoptotic role, BI-1 also enhances cancer/tumor progression. It belongs to the Bcl-2 family, plays an important role in the mitochondrial apoptosis pathway. Bi-1 over-expression suppresses apoptosis induced by Bax, staurosporine and growth factor deprivation. BI-1 is presumably not needed for the physiological regulation of developmental programmed cell death. The anti-apoptotic mechanism of BI-1 involves the suppression of Bax activation and translocation to mitochondria, preserving the mitochondria membrane potential and mitochondrial morphology, and preventing the activation of post-mitochondrial caspases. BI-1 function is also associated with the regulation of intracellular Ca2+ omeostasis. In several human cancers, including nasopharyngeal carcinoma, its expression was found to be increased, however, up-regulated expression of this protein has been linked to increased cell proliferations.

Molecular Weight: 30 kDa

Gene ID: 7009

UniProt: P55061

Pathways: Response to Water Deprivation, ER-Nucleus Signaling