14-3-3 sigma/SFN antibody
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- Target See all 14-3-3 sigma/SFN (SFN) Antibodies
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This 14-3-3 sigma/SFN antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Protein A Chromatography
- Immunogen
- Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody.
- Isotype
- IgG
- Top Product
- Discover our top product SFN Primary Antibody
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anti-Stratifin (SFN) antibody
SFN Reactivity: Human WB, IF, IP, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Stratifin (SFN) (Internal Region) antibodyVerified SFN Reactivity: Human, Mouse, Rat WB, IHC, ELISA Host: Goat Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN Reactivity: Human WB, ELISA, IP, IHC (p) Host: Mouse Monoclonal 3C3 unconjugated
anti-Stratifin (SFN) (C-Term) antibodySFN Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Stratifin (SFN) (AA 140-156) antibodySFN Reactivity: Human, Mouse, Rat WB, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Stratifin (SFN) (AA 222-248), (C-Term) antibodySFN Reactivity: Human WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB27523 unconjugated
anti-Stratifin (SFN) (AA 1-248) antibodySFN Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 2G2 unconjugated
anti-Stratifin (SFN) (AA 1-249) antibodySFN Reactivity: Human WB, IHC, IHC (p) Host: Mouse Monoclonal 3C3 unconjugated
anti-Stratifin (SFN) antibodySFN Reactivity: Human WB, IHC, StM Host: Mouse Monoclonal CPTC-SFN-2 unconjugated
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- Application Notes
- WB: 1-3 μg/mL, IHC: 10 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Target
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Alternative Name
- 14-3-3 sigma (SFN Products)
- Background
- 14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to -irradiation and other DNA-damaging agents. 14-3-3 is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing.
- Molecular Weight
- 32 kDa
- Gene ID
- 2810
- UniProt
- P31947
- Pathways
- p53 Signaling, Myometrial Relaxation and Contraction
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