Fibrillarin/Nop1p Nucleolar Marker antibody
Quick Overview for Fibrillarin/Nop1p Nucleolar Marker antibody (ABIN504711)
Target
Reactivity
Host
Clonality
Application
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Cross-Reactivity
- Caenorhabditis elegans (C. elegans), Fruit Fly (Drosophila melanogaster), Human, Mouse (Murine)
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Purification
- Purified
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Immunogen
- Mice were injected with yeast nuclear preparations and hybridomas were screened by immunofluorescence on yeast cells and by western blotting on yeast protein homogenates.
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Isotype
- IgG
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Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Storage
- -20 °C
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- Fibrillarin/Nop1p Nucleolar Marker
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Background
- The Nop1p protein is 327 amino acids in size (34. 5 kDa), is essential for yeast viability, and is localized in the nucleoli (1). The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein apparently found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein.
Target
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