LDLR antibody (AA 500-550)

Catalog No. ABIN504726

This anti-LDLR antibody is a Rabbit Polyclonal antibody detecting LDLR in WB and IHC. Suitable for Human and Mouse.

Quick Overview for LDLR antibody (AA 500-550) (ABIN504726)

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LDLR Antibody

Binding Specificity: AA 500-550

Cross-Reactivity: Human, Mouse (Murine), Primate

Purification: affinity purified

Immunogen: Synthetic peptide made to an internal portion of the human protein (within AA 500-550). [Swiss-Prot# P01130]

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDL Receptor

Background: The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation--the process of receptor-mediated endocytosis (1). Data suggest that the juxtamembranous region of the cytoplasmic domain participates in protein:protein interactions that allow the low density lipoprotein receptor to cluster in coated pits (2). It has been shown that the family of LDL receptors may serve as viral receptors. Endocytosis of the Flaviviridae viruses, hepatitis C virus, GB virus C/hepatitis G virus, and bovine viral diarrheal virus (BVDV) was shown to be mediated by LDL receptors on cultured cells

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism