Angiopoietin 1 antibody (C-Term)

Catalog No. ABIN504734

The Rabbit Polyclonal anti-Angiopoietin 1 antibody has been validated for WB and IHC. It is suitable to detect Angiopoietin 1 in samples from Human, Mouse and Rabbit.

Quick Overview for Angiopoietin 1 antibody (C-Term) (ABIN504734)

Target: Angiopoietin 1 (ANGPT1)

Reactivity: Human, Mouse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiopoietin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Angiopoietin 1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Dog (Canine), Human, Rabbit, Rat (Rattus)

Purification: affinity purified

Immunogen: C-terminal sequence of human Angiopoietin-1.

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for Angiopoietin 1

Target: Angiopoietin 1 (ANGPT1)

Alternative Name: Angiopoietin-1

Background: Angiopoietin 1 is one of the Angiopoietin (Ang) family of growth factors. It binds and activates the TIE2 receptor tyrosine kinase by inducing its tyrosine phosphorylation. It is implicated in endothelial developmental processes later and distinct from that of VEGF. The structure of angiopoietin 1 differs from that of known angiogenic factors or other ligands for receptor tyrosine kinases. Angiopoietin 1 appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. It also mediates blood vessel maturation/stability and it may play an important role in the heart early development. Angiopoietin 1 may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.

Pathways: RTK Signaling, Glycosaminoglycan Metabolic Process