CD86 antibody (PE)

Catalog No. ABIN5067876

This anti-CD86 antibody is a Mouse Monoclonal antibody detecting CD86 in FACS. Suitable for Human, Cynomolgus, Baboon and Rhesus Monkey.

Quick Overview for CD86 antibody (PE) (ABIN5067876)

Target: CD86

Reactivity: Human, Cynomolgus, Baboon, Rhesus Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD86 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: BU63

Product Details anti-CD86 Antibody (PE)

Purpose: CD86 PE Antibody

Characteristics: BU63 recognizes ~70Kda a surface antigen protein of Ig superfamily characterized as CD86 expressed by most antigen presenting cells (APC). Depending on the immunological condition, CD86 specifically binds with its two ligands CD28 and CD152 (CTLA-4) expressed by T cells. Binding with CD28, CD86 provides stimulatory signal and activates T cells whereas binding with CD152 (CTLA-4) CD86 provides inhibitory signal to T cells. Generally, high-level CD86 expression was noticed on peripheral monocytes, tissue macrophages and dendritic cells, and also on activated B cells. CD86 is useful in the clinical diagnosis of cancer cells including malignant Hodgkin's and non-hodgkin's diseases.

Purification: Purified

Purity: >95 %

Immunogen: B-lymphoblastoid cell line ARH 77

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD86

Target: CD86

Alternative Name: CD86

UniProt: P42081

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation