BST2 antibody (AA 1-180)

Catalog No. ABIN513817

This Mouse Polyclonal antibody specifically detects BST2 in WB, IF and IHC (p). It exhibits reactivity toward Human and has been mentioned in 9+ publications.

Quick Overview for BST2 antibody (AA 1-180) (ABIN513817)

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This BST2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BST2 Antibody

Binding Specificity: AA 1-180

Purpose: Mouse polyclonal antibody raised against a full-length human BST2 protein.

Sequence: MASTSYDYCR VPMEDGDKRC KLLLGIGILV LLIIVILGVP LIIFTIKANS EACRDGLRAV MECRNVTHLL QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS SSAAAPQLLI VLLGLSALLQ

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: BST2 (NP_004326.1, 1 a.a. ~ 180 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-BST2 antibody (ABIN513817)

Edgar, Manna, Nishimura, Banting, Robinson: "Tetherin is an exosomal tether." in: eLife, Vol. 5, (2016) (PubMed).

Brinkmann, Nehlmeier, Walendy-Gnirß, Nehls, González Hernández, Hoffmann, Qiu, Takada, Schindler, Pöhlmann: "The Tetherin Antagonism of the Ebola Virus Glycoprotein Requires an Intact Receptor-Binding Domain and Can Be Blocked by GP1-Specific Antibodies." in: Journal of virology, Vol. 90, Issue 24, pp. 11075-11086, (2016) (PubMed).

Yang, Lopez, Exline, Haworth, Cannon: "Lack of adaptation to human tetherin in HIV-1 group O and P." in: Retrovirology, Vol. 8, pp. 78, (2011) (PubMed).

Gupta, Mlcochova, Pelchen-Matthews, Petit, Mattiuzzo, Pillay, Takeuchi, Marsh, Towers: "Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestration." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 49, pp. 20889-94, (2010) (PubMed).

Hauser, Lopez, Yang, Oldenburg, Exline, Guatelli, Cannon: "HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment." in: Retrovirology, Vol. 7, pp. 51, (2010) (PubMed).

Casartelli, Sourisseau, Feldmann, Guivel-Benhassine, Mallet, Marcelin, Guatelli, Schwartz: "Tetherin restricts productive HIV-1 cell-to-cell transmission." in: PLoS pathogens, Vol. 6, Issue 6, pp. e1000955, (2010) (PubMed).

Karetnikov, Suomalainen: "Tethered virions are intermediates in the assembly and release of HIV-1 particles." in: Virology, Vol. 407, Issue 2, pp. 289-95, (2010) (PubMed).

Lopez, Yang, Hauser, Exline, Haworth, Oldenburg, Cannon: "Ebola virus glycoprotein counteracts BST-2/Tetherin restriction in a sequence-independent manner that does not require tetherin surface removal." in: Journal of virology, Vol. 84, Issue 14, pp. 7243-55, (2010) (PubMed).

Iwabu, Fujita, Kinomoto, Kaneko, Ishizaka, Tanaka, Sata, Tokunaga: "HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes." in: The Journal of biological chemistry, Vol. 284, Issue 50, pp. 35060-72, (2009) (PubMed).

Target Details for BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Alternative Name: BST2

Background: Full Gene Name: bone marrow stromal cell antigen 2
Synonyms: CD317

Gene ID: 684

NCBI Accession: NM_004335

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response