CYP3A4 antibody (AA 1-503)

Catalog No. ABIN514838

The Mouse Polyclonal anti-CYP3A4 antibody has been validated for WB and IHC (p). It is suitable to detect CYP3A4 in samples from Human. There are 3+ publications available.

Quick Overview for CYP3A4 antibody (AA 1-503) (ABIN514838)

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This CYP3A4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CYP3A4 Antibody

Binding Specificity: AA 1-503

Purpose: Mouse polyclonal antibody raised against a full-length human CYP3A4 protein.

Sequence: MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV SGA

Cross-Reactivity: Human

Characteristics: Antibody reactive against mammalian transfected lysate.

Immunogen: CYP3A4 (AAI01632.1, 1 a.a. ~ 503 a.a) full-length human protein.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CYP3A4 antibody (ABIN514838)

Wiegand, Hewitt, Merk, Reisinger: "Dermal xenobiotic metabolism: a comparison between native human skin, four in vitro skin test systems and a liver system." in: Skin pharmacology and physiology, Vol. 27, Issue 5, pp. 263-75, (2014) (PubMed).

Fahrmayr, König, Auge, Mieth, Münch, Segrestaa, Pfeifer, Treiber, Fromm: "Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line." in: British journal of pharmacology, Vol. 169, Issue 1, pp. 21-33, (2013) (PubMed).

Yamashita, Honda, Nio, Nakamoto, Yamashita, Takamura, Tani, Zen, Kaneko: "Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation." in: Cancer research, Vol. 70, Issue 11, pp. 4687-97, (2010) (PubMed).

Target Details for CYP3A4

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Alternative Name: CYP3A4

Background: Full Gene Name: cytochrome P450, family 3, subfamily A, polypeptide 4
Synonyms: CP33,CP34,CYP3A,CYP3A3,HLP,MGC126680,NF-25,P450C3,P450PCN1

Gene ID: 1576

NCBI Accession: NM_017460

Pathways: Steroid Hormone Biosynthesis