SIRT6 antibody (AA 141-250)

Catalog No. ABIN526804

This Mouse Monoclonal antibody specifically detects SIRT6 in ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for SIRT6 antibody (AA 141-250) (ABIN526804)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: ELISA

Clone: 1D8

Product Details anti-SIRT6 Antibody

Binding Specificity: AA 141-250

Purpose: Mouse monoclonal antibody raised against a partial recombinant SIRT6.

Sequence: CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: SIRT6 (NP_057623.1, 141 a.a. ~ 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-SIRT6 antibody (ABIN526804)

Azuma, Yokobori, Mogi, Altan, Yajima, Kosaka, Onozato, Yamaki, Asao, Nishiyama, Kuwano: "SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer." in: Journal of surgical oncology, Vol. 112, Issue 2, pp. 231-7, (2015) (PubMed).

Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: "Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses." in: PLoS ONE, Vol. 7, Issue 7, pp. e39847, (2012) (PubMed).

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background: Full Gene Name: sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
Synonyms: SIR2L6

Gene ID: 51548

NCBI Accession: NM_016539