Glucosylceramidase antibody (N-Term)

Catalog No. ABIN5514399

This Rabbit Polyclonal antibody specifically detects Glucosylceramidase in WB. It exhibits reactivity toward Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit and Rat.

Quick Overview for Glucosylceramidase antibody (N-Term) (ABIN5514399)

Target: Glucosylceramidase (GLCM)

Reactivity: Human, Mouse, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glucosylceramidase antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Glucosylceramidase Antibody

Binding Specificity: N-Term

Sequence: FSSPSREECP KPLSRVSIMA GSLTGLLLLQ AVSWASGARP CIPKSFGYSS

Predicted Reactivity: Cow: 75%, Dog: 75%, Guinea Pig: 75%, Horse: 75%, Human: 100%, Mouse: 75%, Pig: 79%, Rabbit: 75%, Rat: 75%

Characteristics: This is a rabbit polyclonal antibody against GLCM. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human GLCM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Glucosylceramidase

Target: Glucosylceramidase (GLCM)

Alternative Name: GLCM

Background: This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants.

Alias Symbols: GBA, GC, GLUC,

Protein Interaction Partner: NUDCD1, UBC, ITCH, ATP6V1B1, SNCA, FBXO6, TCP1, CBL, NEDD4, PARK2, HSP90AA1, HSPA4, PSAP,

Protein Size: 536

Gene ID: 2629

NCBI Accession: XP_006711333

UniProt: P04062