ROA1 antibody (C-Term)

Catalog No. ABIN5514461

This anti-ROA1 antibody is a Rabbit Polyclonal antibody detecting ROA1 in WB. Suitable for Human.

Quick Overview for ROA1 antibody (C-Term) (ABIN5514461)

Target: ROA1 (OPA6) (Optic Atrophy 6 (Autosomal Recessive) (OPA6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Product Details anti-ROA1 Antibody

Binding Specificity: C-Term

Sequence: GSGYGGSGSY DSYNNGGGGG FGGGSGSNFG GGGSYNDFGN YNNQSSNFGP

Characteristics: This is a rabbit polyclonal antibody against ROA1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ROA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ROA1

Target: ROA1 (OPA6) (Optic Atrophy 6 (Autosomal Recessive) (OPA6))

Alternative Name: ROA1

Background: This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.

Alias Symbols: HNRNPA1, HNRPA1,

Protein Size: 372

Gene ID: 3178

NCBI Accession: XP_005268883

UniProt: P09651