Complement Factor B antibody (N-Term)

Catalog No. ABIN5514558

This Rabbit Polyclonal antibody specifically detects Complement Factor B in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit and Sheep.

Quick Overview for Complement Factor B antibody (N-Term) (ABIN5514558)

Target: Complement Factor B (CFB)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Complement Factor B Antibody

Binding Specificity: N-Term

Sequence: NGAGYCSNPG IPIGTRKVGS QYRLEDSVTY HCSRGLTLRG SQRRTCQEGG

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against CFAB. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CFAB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: CFAB

Background: CFAB is a factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Alias Symbols: CFB, BF, BFD,

Protein Interaction Partner: FN1, LAMC3, RPA2, ALB, CFP, C3,

Protein Size: 764

Gene ID: 629

NCBI Accession: NP_001701

UniProt: P00751

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process