Complement Factor I antibody (C-Term)

Catalog No. ABIN5514688

The Rabbit Polyclonal anti-Complement Factor I antibody has been validated for WB. It is suitable to detect Complement Factor I in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig and Rabbit.

Quick Overview for Complement Factor I antibody (C-Term) (ABIN5514688)

Target: Complement Factor I (CFI)

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor I antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Complement Factor I Antibody

Binding Specificity: C-Term

Sequence: AGTYDGSIDA CKGDSGGPLV CMDANNVTYV WGVVSWGENC GKPEFPGVYT

Predicted Reactivity: Cow: 77%, Dog: 77%, Guinea Pig: 79%, Horse: 83%, Human: 100%, Mouse: 86%, Pig: 85%, Rabbit: 83%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against CFI. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CFI

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Complement Factor I

Target: Complement Factor I (CFI)

Alternative Name: CFI

Background: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

Alias Symbols: CFI, IF,

Protein Interaction Partner: GLP1R, CFH, C3,

Protein Size: 583

Gene ID: 3426

NCBI Accession: NM_000204, NP_000195

UniProt: P05156

Pathways: Complement System