CYP11A1 antibody (Middle Region)

Catalog No. ABIN5514801

This Rabbit Polyclonal antibody specifically detects CYP11A1 in WB. It exhibits reactivity toward Human, Pig and Rabbit.

Quick Overview for CYP11A1 antibody (Middle Region) (ABIN5514801)

Target: CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))

Reactivity: Human, Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP11A1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CYP11A1 Antibody

Binding Specificity: Middle Region

Sequence: AWDVIFSKAD IYTQNFYWEL RQKGSVHHDY RGILYRLLGD SKMSFEDIKA

Predicted Reactivity: Human: 100%, Pig: 75%, Rabbit: 83%

Characteristics: This is a rabbit polyclonal antibody against CP11A. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human CP11A

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CYP11A1

Target: CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))

Alternative Name: CP11A

Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.

Alias Symbols: CYP11A1, CYP11A,

Protein Interaction Partner: SMAD9, SMAD3, SMAD2, CYP11B2, FDX1,

Protein Size: 363

Gene ID: 1583

NCBI Accession: NP_001093243

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin