Histone H3.3 antibody (N-Term)
Quick Overview for Histone H3.3 antibody (N-Term) (ABIN5514837)
Target
See all Histone H3.3 (H3F3A) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- N-Term
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Sequence
- RTKQTARKST GGKAPRKQLA TKAARKSAPS TGGVKKPHRY RPGTVALREI
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Characteristics
- This is a rabbit polyclonal antibody against H3F3A. It was validated on Western Blot.
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Purification
- Affinity Purified
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Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human H3F3A
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C
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Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Histone H3.3 (H3F3A) (H3 Histone, Family 3A (H3F3A))
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Alternative Name
- H3F3A
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Background
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
Alias Symbols: H3F3A, H3.3B,
Protein Interaction Partner: FUS, DAXX, CENPA, ATRX, ZMYND11, HIST1H4A, UBC, PML, H2AFY, UHRF1, ASB9, ASB16, ASB2, RNF2, CORO1C, PUF60, NUDC, VPS26A, SNX2, PAWR, VPS35, VPS29, FAM129B, SNX6, ASF1B, ASF1A, HIRA, CHAF1A, ITGA4, HIST4H4, NOS3, LRRK2, HIST1H4F, KDM4A, SSRP1, BRD1, EFS, S
Protein Size: 136 -
Gene ID
- 3020
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NCBI Accession
- NP_005315
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UniProt
- P84243
Target
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