IL-7 antibody (C-Term)

Catalog No. ABIN5514877

The Rabbit Polyclonal anti-IL-7 antibody has been validated for WB. It is suitable to detect IL-7 in samples from Human, Pig, Cow, Dog, Horse, Saccharomyces cerevisiae and Sheep.

Quick Overview for IL-7 antibody (C-Term) (ABIN5514877)

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Reactivity: Human, Pig, Cow, Dog, Horse, Saccharomyces cerevisiae, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL-7 Antibody

Binding Specificity: C-Term

Sequence: LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC

Predicted Reactivity: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Pig: 100%, Sheep: 93%, Yeast: 85%

Characteristics: This is a rabbit polyclonal antibody against IL7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human IL7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for IL-7

Target: IL-7 (IL7) (Interleukin 7 (IL7))

Alternative Name: IL7

Background: The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.

Alias Symbols: IL7,

Protein Interaction Partner: CEBPE, APP, IL2RG, IL7R,

Protein Size: 177

Gene ID: 3574

UniProt: P13232

Pathways: JAK-STAT Signaling