alpha Fetoprotein antibody (C-Term)

Catalog No. ABIN7482644

The Rabbit Polyclonal anti-alpha Fetoprotein antibody is suitable to detect alpha Fetoprotein in samples from Human, Mouse, Rat, Pig, Dog, Cow and Horse. It has been validated for WB.

Quick Overview for alpha Fetoprotein antibody (C-Term) (ABIN7482644)

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Reactivity: Human, Mouse, Rat, Pig, Dog, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha Fetoprotein antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-alpha Fetoprotein Antibody

Binding Specificity: C-Term

Sequence: KPQITEEQLE AVIADFSGLL EKCCQGQEQE VCFAEEGQKL ISKTRAALGV

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 91%, Pig: 91%, Rat: 91%

Characteristics: This is a rabbit polyclonal antibody against AFP. It was validated on Western Blot.

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human AFP

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for alpha Fetoprotein

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Alternative Name: AFP

Background: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

Alias Symbols: FETA, HPAFP

Protein Interaction Partner: PIDD1, EHD4, PHB2, AP4S1, MED27, PSMB7, GNB1, XIAP, STAMBP, SGSM2, CCR5,

Protein Size: 609

Gene ID: 174

NCBI Accession: NM_001134, NP_001125

UniProt: P02771

Pathways: C21-Steroid Hormone Metabolic Process