RAD51 antibody (N-Term)

Catalog No. ABIN5515419

This Rabbit Polyclonal antibody specifically detects RAD51 in WB. It exhibits reactivity toward Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse and Dog.

Quick Overview for RAD51 antibody (N-Term) (ABIN5515419)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Guinea Pig, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAD51 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RAD51 Antibody

Binding Specificity: N-Term

Sequence: QLEANADTSV EEESFGPQPI SRLEQCGINA NDVKKLEEAG FHTVEAVAYA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 94%, Human: 100%, Mouse: 100%, Rabbit: 94%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RAD51. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RAD51

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Alternative Name: RAD51

Background: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Alias Symbols: Name=RAD51,

Protein Interaction Partner: BRCA1, ATRX, FBXO18, PALB2, HNRNPC, SWSAP1, HNRNPA2B1, RPA3, RPA1, RAD52, PFN1, RAD54B, AICDA, BLM, DMC1, NXF1, RECQL5, UGDH, CHEK1, BRCA2, SFR1, SWI5, NEDD8, PML, TERF2IP, TP53, MSH2, MSH6, UBC, UHRF2, RAD51AP1, WRN, POLN, MORF4L1, MDC1, RAD51C, MCPH1, S

Protein Size: 339

Gene ID: 5888

UniProt: Q06609

Pathways: DNA Damage Repair