ADD2 antibody (C-Term)

Catalog No. ABIN5515464

This Rabbit Polyclonal antibody specifically detects ADD2 in WB. It exhibits reactivity toward Human.

Quick Overview for ADD2 antibody (C-Term) (ABIN5515464)

Target: ADD2 (Adducin 2 (Beta) (ADD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADD2 Antibody

Binding Specificity: C-Term

Sequence: SAGPQSQLLA SVIAEKSRSP STESQLMSKG DEDTKDDSEE TVPNPFSQLT

Characteristics: This is a rabbit polyclonal antibody against ADDB. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen for Anti-ADD2 antibody is: synthetic peptide directed towards the C-terminal region of Human ADDB

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ADD2

Target: ADD2 (Adducin 2 (Beta) (ADD2))

Alternative Name: ADD2

Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

Alias Symbols: ADDB,

Protein Size: 726

Gene ID: 119

UniProt: P35612

Pathways: Regulation of Actin Filament Polymerization