Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ADD2 antibody

ADD2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7128257
  • Target See all ADD2 Antibodies
    ADD2 (Adducin 2 (Beta) (ADD2))
    Reactivity
    • 28
    • 24
    • 9
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 41
    • 2
    Rabbit
    Clonality
    • 43
    Polyclonal
    Conjugate
    • 22
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADD2 antibody is un-conjugated
    Application
    • 36
    • 13
    • 13
    • 10
    • 8
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of Human ADD2
    Isotype
    IgG
    Top Product
    Discover our top product ADD2 Primary Antibody
  • Application Notes
    ELISA:1:1000-1:2000, IHC:1:15-1:50,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    ADD2 (Adducin 2 (Beta) (ADD2))
    Alternative Name
    ADD2 (ADD2 Products)
    Synonyms
    si:dkey-202n14.5 antibody, ADDB antibody, 2900072M03Rik antibody, add97 antibody, beta-ADD antibody, adducin 2 antibody, adducin 2 (beta) antibody, ADD2 antibody, add2 antibody, Add2 antibody
    Background

    Background: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described.

    Aliases: ADD 2 antibody, ADD2 antibody, ADDB antibody, ADDB_HUMAN antibody, Adducin 2 (beta) antibody, Adducin2 antibody, Beta adducin antibody, Beta-adducin antibody, Erythrocyte adducin subunit beta antibody, OTTHUMP00000203378 antibody, OTTHUMP00000203908 antibody

    UniProt
    P35612
    Pathways
    Regulation of Actin Filament Polymerization
You are here:
Support