CAMLG antibody (C-Term)

Catalog No. ABIN5515470

This Rabbit Polyclonal antibody specifically detects CAMLG in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit and Saccharomyces cerevisiae.

Quick Overview for CAMLG antibody (C-Term) (ABIN5515470)

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMLG antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CAMLG Antibody

Binding Specificity: C-Term

Sequence: LISEKPSQED GNTTEEFDSF RIFRLVGCAL LALGVRAFVC KYLSIFAPFL

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 79%, Rat: 93%, Yeast: 90%

Characteristics: This is a rabbit polyclonal antibody against CAMLG. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human CAMLG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CAMLG

Target: CAMLG (Calcium Modulating Ligand (CAMLG))

Alternative Name: CAMLG

Background: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Alias Symbols: CAMLG, CAML,

Protein Interaction Partner: KCNA2, TMUB1, TNFRSF13B, UBC, RNF122, PKHD1, EGFR, PPIB, IER3,

Protein Size: 296

Gene ID: 819

NCBI Accession: NP_001736

UniProt: P49069

Pathways: EGFR Signaling Pathway