MAP3K7 antibody (C-Term)

Catalog No. ABIN5516090

This anti-MAP3K7 antibody is a Rabbit Polyclonal antibody detecting MAP3K7 in WB. Suitable for Human.

Quick Overview for MAP3K7 antibody (C-Term) (ABIN5516090)

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAP3K7 Antibody

Binding Specificity: C-Term

Sequence: VTGTEPGQVS SRSSSPSVRM ITTSGPTSEK PTRSHPWTPD DSTDTNGSDN

Characteristics: This is a rabbit polyclonal antibody against MAP3K7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MAP3K7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAP3K7

Target: MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Alternative Name: MAP3K7

Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alias Symbols: MAP3K7, TAK1,

Protein Interaction Partner: MAGED1, UBC, TRAF6, HSPB1, TAB2, IKBKB, TRAF4, TGFBR1, MAP3K7, MAP2K6, MAPK8, NAIP, XIAP, RIPK1, TIRAP, TAB1, SIK1, SIK3, SYK, SASH1, IRAK1, TNFRSF1A, MAPK8IP1, RIPK2, IKBKG, VRK2, MAP2K4, NOD2, PRKCQ, PPM1L, SKIL, PPP6C, PPP2R1A, MAP3K3, BST2, PINK1, MAL

Protein Size: 579

Gene ID: 6885

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway