RASA1 antibody (N-Term)

Catalog No. ABIN5516840

The Rabbit Polyclonal anti-RASA1 antibody (ABIN5516840) specifically detects RASA1 in WB. The antibody is reactive with Human samples.

Quick Overview for RASA1 antibody (N-Term) (ABIN5516840)

Target: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RASA1 Antibody

Binding Specificity: N-Term

Sequence: GTVDEGDSLD GPEYEEEEVA IPLTAPPTNQ WYHGKLDRTI AEERLRQAGK

Characteristics: This is a rabbit polyclonal antibody against RASA1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human RASA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RASA1

Target: RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))

Alternative Name: RASA1

Background: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Alias Symbols: RASA1, GAP, RASA,

Protein Interaction Partner: ARHGAP35, DOK1, KHDRBS1, DOK2, PLCG1, EGFR, ABL1, Mbp, ERBB4, ERBB3, ERBB2, APP, SOCS1, UBC, SPSB1, ZNF579, BBS10, TRMT2A, EIF1, SERPINA4, XRCC6, EZH2, NCK1, BTRC, NFKBIA, DOK4, AFAP1L2, DNAJA3, G3BP1, PAG1, AURKB, MAP4K4, SOCS3, BIRC5, ARHGAP1, ARHGAP5,

Protein Size: 1047

Gene ID: 5921

UniProt: P20936

Pathways: Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals