FBXL15 antibody (N-Term)

Catalog No. ABIN5517039

This Rabbit Polyclonal antibody specifically detects FBXL15 in WB. It exhibits reactivity toward Human, Cow, Dog, Goat, Horse, Mouse, Rabbit and Rat.

Quick Overview for FBXL15 antibody (N-Term) (ABIN5517039)

Target: FBXL15 (F-Box and Leucine-Rich Repeat Protein 15 (FBXL15))

Reactivity: Human, Cow, Dog, Goat, Horse, Mouse, Rabbit, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXL15 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXL15 Antibody

Binding Specificity: N-Term

Sequence: PPMEPSGGEQ EPGAVRFLDL PWEDVLLPHV LNRVPLRQLL RLQRVSRAFR

Predicted Reactivity: Cow: 93%, Dog: 100%, Goat: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against FBXL15. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human FBXL15

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXL15

Target: FBXL15 (F-Box and Leucine-Rich Repeat Protein 15 (FBXL15))

Alternative Name: FBXL15

Background: FBXL15 is a substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance and also mediates ubiquitination of SMURF2 and WWP2.

Alias Symbols: FBXO37, Fbl15, JET, PSD

Protein Interaction Partner: HNRNPD, SKP1, ITCH, SMURF2, HECW2, SMURF1, NEDD4L, HECW1, WWP2, WWP1, RBX1, CUL1, NEDD4, HSP90AA1, COPS6, UBC,

Protein Size: 300

Gene ID: 79176

NCBI Accession: NM_024326, NP_077302

UniProt: Q9H469