UBXN1 antibody (N-Term)

Catalog No. ABIN5517553

The Rabbit Polyclonal anti-UBXN1 antibody has been validated for WB. It is suitable to detect UBXN1 in samples from Human.

Quick Overview for UBXN1 antibody (N-Term) (ABIN5517553)

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBXN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-UBXN1 Antibody

Binding Specificity: N-Term

Sequence: GRAEKALALT GNQGIEAAMD WLMEHEDDPD VDEPLETPLG HILGREPTSS

Characteristics: This is a rabbit polyclonal antibody against UBXN1. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human UBXN1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for UBXN1

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Alternative Name: UBXN1

Background: UBXN1 is a ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. It specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1,it leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. It is a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.

Alias Symbols: UBXN1, SAKS1,

Protein Interaction Partner: UBXN1, UBQLN1, FAM189A2, PLAA, TRIM39, VCP, UBE2I, UBC, PLA2G4A, MAVS, NSFL1C, STK26, TRNT1, MCTS1, TWF2, PROSC, BASP1, DENR, YWHAE, TXNRD1, TUFM, TUBB2A, PAFAH1B1, HSPA5, HMGB3, HK1, CTPS1, CAPN2, CD81, CSE1L, CLNS1A, ATP6V1A, SSSCA1, USP34, SEC22B, VPS4

Protein Size: 297

Gene ID: 51035

UniProt: Q04323