ZCCHC6 antibody (N-Term)

Catalog No. ABIN5517595

The Rabbit Polyclonal anti-ZCCHC6 antibody has been validated for WB. It is suitable to detect ZCCHC6 in samples from Human.

Quick Overview for ZCCHC6 antibody (N-Term) (ABIN5517595)

Target: ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZCCHC6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ZCCHC6 Antibody

Binding Specificity: N-Term

Sequence: SPENKKQRSR PRKPRKTRNE ENEQDGDLEG PVIDESVLST KELLGLQQAE

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ZCCHC6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ZCCHC6

Target: ZCCHC6 (Zinc Finger, CCHC Domain Containing 6 (ZCCHC6))

Alternative Name: ZCCHC6

Background: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Alias Symbols: TUT7, PAPD6

Protein Size: 544

Gene ID: 79670

NCBI Accession: NM_001185059, NP_001171988