COQ3 antibody (N-Term)

Catalog No. ABIN5517894

This Rabbit Polyclonal antibody specifically detects COQ3 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse and Pig.

Quick Overview for COQ3 antibody (N-Term) (ABIN5517894)

Target: COQ3 (Coenzyme Q3, Methyltransferase (COQ3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COQ3 Antibody

Binding Specificity: N-Term

Sequence: ARLYSTSQTT VDSGEVKTFL ALAHKWWDEQ GVYAPLHSMN DLRVPFIRDN

Predicted Reactivity: Cow: 79%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 92%, Pig: 79%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against COQ3. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human COQ3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COQ3

Target: COQ3 (Coenzyme Q3, Methyltransferase (COQ3))

Alternative Name: COQ3

Background: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.

Alias Symbols: COQ3, UG0215E05,

Protein Size: 369

Gene ID: 51805

NCBI Accession: NP_059117

UniProt: Q9NZJ6

Pathways: Methionine Biosynthetic Process