COQ3 antibody (Middle Region)

Catalog No. ABIN5517895

The Rabbit Polyclonal anti-COQ3 antibody has been validated for WB. It is suitable to detect COQ3 in samples from Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for COQ3 antibody (Middle Region) (ABIN5517895)

Target: COQ3 (Coenzyme Q3, Methyltransferase (COQ3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COQ3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COQ3 Antibody

Binding Specificity: Middle Region

Sequence: CGGGLLTEPL GRLGASVIGI DPVDENIKTA QCHKSFDPVL DKRIEYRVCS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against COQ3. It was validated on Western Blot.

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human COQ3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COQ3

Target: COQ3 (Coenzyme Q3, Methyltransferase (COQ3))

Alternative Name: COQ3

Background: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.

Alias Symbols: COQ3, UG0215E05,

Protein Size: 369

Gene ID: 51805

NCBI Accession: NP_059117

UniProt: Q9NZJ6

Pathways: Methionine Biosynthetic Process