COBRA1 antibody (N-Term)

Catalog No. ABIN5518104

This Rabbit Polyclonal antibody specifically detects COBRA1 in WB. It exhibits reactivity toward Human.

Quick Overview for COBRA1 antibody (N-Term) (ABIN5518104)

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COBRA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-COBRA1 Antibody

Binding Specificity: N-Term

Sequence: NCTEPLKAIE QFQTENGVLL PSLQSALPFL DLHGTPRLEF HQSVFDELRD

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Yeast: 90%

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human COBRA1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: COBRA1

Background: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2, MIM 606026), either NELFC or NELFD (TH1L, MIM 605297), and NELFE (RDBP, MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1, MIM 603555) and SPT5 (SUPT5H, MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

Alias Symbols: COBRA1, NELF-B

Protein Interaction Partner: UBC, ABCF1, DIMT1, EDC4, IGF2BP3, SYNCRIP, EIF2B2, EIF2B3, EIF3C, YBX3, RPL23A, RFC4, PTBP1, PA2G4, YBX1, NMT1, MRE11A, ILF2, HNRNPU, FKBP3, DHX9, DDX1, KHDRBS3, DENR, YWHAB, MGST1, HSPA9, Dlg4, POLR2C, NELFB, SUPT5H, POLR2A, ATP1A1, ALDH3A2, NELFCD, CCT8

Protein Size: 580

Gene ID: 25920

NCBI Accession: NM_015456, NP_056271

UniProt: Q8WX92