CRX antibody (C-Term)

Catalog No. ABIN5518821

This Rabbit Polyclonal antibody specifically detects CRX in WB. It exhibits reactivity toward Human.

Quick Overview for CRX antibody (C-Term) (ABIN5518821)

Target: CRX (Cone-Rod Homeobox (CRX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CRX Antibody

Binding Specificity: AA 265-299, C-Term

Purpose: Anti-CORD2/CRX Antibody Picoband®

Sequence: DSLEFKDPTG TWKFTYNPMD PLDYKDQSAW KFQIL

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-CORD2/CRX Antibody Picoband® (ABIN5518821). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CORD2, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Freund CL, Gregory-Evans CY, Furukawa T, Papaioannou M, Looser J, Ploder L, Bellingham J, Ng D, Herbrick JA, Duncan A, Scherer SW, Tsui LC, Loutradis-Anagnostou A, Jacobson SG, Cepko CL, Bhattacharya SS, McInnes RR (Nov 1997). "Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor". Cell. 91 (4): 543-53. 2. Freund CL, Wang QL, Chen S, Muskat BL, Wiles CD, Sheffield VC, Jacobson SG, McInnes RR, Zack DJ, Stone EM (Apr 1998). "De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis". Nature Genetics. 18 (4): 311-2.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for CRX

Target: CRX (Cone-Rod Homeobox (CRX))

Alternative Name: CRX

Background:

Synonyms: Cone-rod homeobox protein,CRX,CORD2,

Tissue Specificity: Retina.

Background: Cone-rod homeobox protein is a protein that in humans is encoded by the CRX gene. The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

Molecular Weight: 37 kDa

Gene ID: 1406

UniProt: O43186