TSH receptor antibody (N-Term)

Catalog No. ABIN5518887

This Rabbit Polyclonal antibody specifically detects TSH receptor in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TSH receptor antibody (N-Term) (ABIN5518887)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSH receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TSH receptor Antibody

Binding Specificity: AA 244-277, N-Term

Purpose: Anti-TSH Receptor/TSHR Antibody

Sequence: KGLEHLKELI ARNTWTLKKL PLSLSFLHLT RADL

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-TSH Receptor/TSHR Antibody (ABIN5518887). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TSH Receptor, different from the related mouse sequence by two amino acids, and from the related rat sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Alternative Name: TSHR

Background:

Synonyms: Thyrotropin receptor,Thyroid-stimulating hormone receptor,TSH-R,TSHR,LGR3,

Tissue Specificity: Expressed in the thyroid. .

Background: TSHR (Thyroid-Stimulating Hormone Receptor), also called LGR3, is mapped to 14q31.1. The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 86 kDa

Gene ID: 7253

UniProt: P16473

Pathways: Thyroid Hormone Synthesis