SIX Homeobox 6 antibody (AA 188-246)

Catalog No. ABIN5518956

This Rabbit Polyclonal antibody specifically detects SIX Homeobox 6 in WB. It exhibits reactivity toward Human.

Quick Overview for SIX Homeobox 6 antibody (AA 188-246) (ABIN5518956)

Target: SIX Homeobox 6 (SIX6)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIX Homeobox 6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIX Homeobox 6 Antibody

Binding Specificity: AA 188-246

Purpose: Anti-Homeobox protein SIX6 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Homeobox protein SIX6 Antibody Picoband® (ABIN5518956). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human SIX6 recombinant protein (Position: A188-I246). Human SIX6 shares 91.5% amino acid (aa) sequence identity with mouse SIX6.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Aijaz, S., Clark, B. J., Williamson, K., van Heyningen, V., Morrison, D., FitzPatrick, D., Collin, R., Ragge, N., Christoforou, A., Brown, A., Hanson, I. Absence of SIX6 mutations in microphthalmia, anophthalmia, and coloboma. Invest. Ophthal. Vis. Sci. 45: 3871-3876, 2004. 2. Aldahmesh, M. A., Khan, A. O., Hijazi, H., Alkuraya, F. S. Homozygous truncation of SIX6causes complex microphthalmia in humans. (Letter) Clin. Genet. 84: 198-199, 2013. 3. Gallardo, M. E., Rodriguez de Cordoba, S., Schneider, A. S., Dwyer, M. A., Ayuso, C., Bovolenta, P. Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia/microphthalmia. (Letter) Am. J. Med. Genet. 129A: 92-94, 2004.

Comment:

We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for SIX Homeobox 6

Target: SIX Homeobox 6 (SIX6)

Alternative Name: SIX6

Background:

Synonyms: Homeobox protein SIX6,Homeodomain protein OPTX2,Optic homeobox 2,Sine oculis homeobox homolog 6,SIX6,OPTX2, SIX9,

Tissue Specificity: Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.

Background: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).

Molecular Weight: 28 kDa

Gene ID: 4990

UniProt: O95475