XPO5 antibody (N-Term)

Catalog No. ABIN5518968

This Rabbit Polyclonal antibody specifically detects XPO5 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for XPO5 antibody (N-Term) (ABIN5518968)

Target: XPO5 (Exportin 5 (XPO5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPO5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-XPO5 Antibody

Binding Specificity: AA 2-43, N-Term

Purpose: Anti-Exportin-5/XPO5 Antibody Picoband®

Sequence: AMDQVNALCE QLVKAVTVMM DPNSTQRYRL EALKFCEEFK EK

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Exportin-5/XPO5 Antibody Picoband® (ABIN5518968). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Exportin-5, different from the related mouse sequence by four amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D (Nov 2002). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". The EMBO Journal. 21 (22): 6205-15. 2. Siomi H, Siomi MC (May 2010). "Posttranscriptional regulation of microRNA biogenesis in animals". Molecular Cell. 38 (3): 323-32.

Comment:

We recommend Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for XPO5

Target: XPO5 (Exportin 5 (XPO5))

Alternative Name: XPO5

Background:

Synonyms: Exportin-5,Exp5,Ran-binding protein 21,XPO5,KIAA1291, RANBP21,

Tissue Specificity: Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas. .

Background: Exportin-5 (XPO5) is a protein that in humans is encoded by the XPO5 gene. The International Radiation Hybrid Mapping Consortium mapped the XPO5 gene to chromosome 6. This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process.

Molecular Weight: 136 kDa

Gene ID: 57510

Pathways: Regulatory RNA Pathways, Protein targeting to Nucleus