Aconitase 1 antibody (AA 354-388)

Catalog No. ABIN5531479

This anti-Aconitase 1 antibody is a Rabbit Polyclonal antibody detecting Aconitase 1 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for Aconitase 1 antibody (AA 354-388) (ABIN5531479)

Target: Aconitase 1 (ACO1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aconitase 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Aconitase 1 Antibody

Binding Specificity: AA 354-388

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ACO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 354-388 amino acids from the Central region of human ACO1.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Aconitase 1

Target: Aconitase 1 (ACO1)

Alternative Name: ACO1

Background: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.

Molecular Weight: 98 kDa

Gene ID: 48

UniProt: P21399

Pathways: Transition Metal Ion Homeostasis