NOG antibody (AA 84-111)

Catalog No. ABIN5531744

This Rabbit Polyclonal antibody specifically detects NOG in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for NOG antibody (AA 84-111) (ABIN5531744)

Target: NOG (Noggin (NOG))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOG antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NOG Antibody

Binding Specificity: AA 84-111

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-111 amino acids from the Central region of human NOG.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for NOG

Target: NOG (Noggin (NOG))

Alternative Name: NOG

Background: The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified, both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

Molecular Weight: 26 kDa

Gene ID: 9241

UniProt: Q13253

Pathways: Stem Cell Maintenance, Tube Formation