RBM5 antibody (N-Term)

Catalog No. ABIN5532044

This Rabbit Polyclonal antibody specifically detects RBM5 in WB. It exhibits reactivity toward Human.

Quick Overview for RBM5 antibody (N-Term) (ABIN5532044)

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RBM5 Antibody

Binding Specificity: AA 18-46, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RBM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human RBM5.

Isotype: Ig Fraction

Application Details

Application Notes: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RBM5

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Alternative Name: RBM5

Background: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Molecular Weight: 92 kDa

Gene ID: 10181

UniProt: P52756

Pathways: Ribonucleoprotein Complex Subunit Organization