USP4 antibody (Ubiquitin Specific Peptidase 4) (AA 903-933) Primary Antibody
USP4 Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal
Catalog No. ABIN5537687
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- Binding Specificity
- AA 903-933, C-Term
- This USP4 antibody is un-conjugated
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- This USP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 903-933 amino acids from the C-terminal region of human USP4.
- Ig Fraction
- Application Notes
- For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
- For Research Use only
- 2 mg/mL
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Alternative Name
- USP4 (USP4 Antibody Abstract)
- Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
- Molecular Weight
- 109 kDa
- Gene ID
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